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All Posts

  • bioinformatics (33)
  • how-to (27)
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  • crispr (19)
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  • Gene ontology and pathway enrichment analysis in R with clusterProfiler
    Published on
    June 28, 2026

    Gene ontology and pathway enrichment analysis in R with clusterProfiler

    how-toRbioinformaticsr-seriesrna-seq
    You ran DESeq2 and got your list of differentially expressed genes. Now what? Here is how to use clusterProfiler to find out which biological pathways are actually changing in your experiment — with real code, real output, and real plots.
  • Python for biologists: getting started (and how it compares to R)
    Published on
    June 23, 2026

    Python for biologists: getting started (and how it compares to R)

    how-topythonbioinformaticsr-seriesbeginner
    You already know R. Do you need Python too? An honest answer — plus a practical guide to getting your first Python environment running and your first biological data analyzed.
  • How to review a bioinformatics analysis as a bench biologist: 6 checks you can actually do
    Published on
    June 16, 2026

    How to review a bioinformatics analysis as a bench biologist: 6 checks you can actually do

    bioinformaticsrna-seqreviewingbench-biologisthow-to
    You don’t need a PhD in computational biology to catch a flawed bioinformatics analysis. These six checks — from public data availability to honest figure design — will let you review computational work with the same rigor you bring to a Western blot.
  • AI in Biology in 2026: From Structural Predictions to Autonomous Wet Labs
    Published on
    June 1, 2026

    AI in Biology in 2026: From Structural Predictions to Autonomous Wet Labs

    bioinformaticsAIprotein-designesm3alphafold3trends
    An in-depth review of the major AI breakthroughs transforming molecular biology in 2026 — from zero-shot protein generation with ESM-3 to automated wet-lab validation loops.
  • Detecting off-targets in the lab: GUIDE-seq, CIRCLE-seq, and Digenome-seq compared
    Published on
    May 21, 2026

    Detecting off-targets in the lab: GUIDE-seq, CIRCLE-seq, and Digenome-seq compared

    how-tocrisprbioinformaticsoff-targetsequencing
    An overview and comparison of laboratory methods for finding CRISPR off-target editing. We compare GUIDE-seq, CIRCLE-seq, Digenome-seq, and DISCOVER-seq to help you choose the right validation tool.
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